genetic testing

At Doodle’s Kennel, we realize the importance of the dam, sire and offspring’s health and we take it very seriously.  The last thing we want to do is produce pups with genetic disease.  Therefore, our dam and sire undergo a variety of testing before being bred.  The testing below is the recommended testing from Veterinarians.

 

Centronuclear Myopathy

An inherited progressive muscle disease affecting dogs, though the severity of symptoms is variable affected dogs typically present between 6 weeks to 7 months of age with excessive intolerance, awkward gait and difficulty eating.  As the disease progresses, symptoms include generalized muscle Atrophy, downward flexion of the head and neck, low muscle tone and more frequent episodes of collapse when exposed to cold temps. Genetic testing of the PTTPLA gene in Labradoodles will reliably determine whether a dog s a genetic carrier of Centronuclear Myopathy. 

Degenerative Myelopathy

An inherited disorder caused by a mutation of the SODI gene, this is carried by any breeds of dog. Though it is not clear for some breeds, such as the Labradoodle whether all dogs carrying two copies of the mutation develop the disease.   The variable presentation between breeds suggests that there are environmental or other genetic factors responsible for modifying diseases expression.  The average age of onset for dogs with degenerative myelopathy is approximately nine years of age.  Genetic Testing of the SODI Gene will reliably determine whether a dog is a genetic carrier of degenerative myelopathy.

Exercise Induced Collapse (EIC)

An inherited neuromuscular disorder affecting Labradoodles.  EIC presents exercise intolerance in apparently healthy dogs.  Affected dogs are usually diagnosed within two years of age. Genetic testing of the DNMI gene will reliably determine whether a dig is a genetic carrier of the gene.

 

Hereditary Nasal Parakeratosis

Inherited disease affecting he nose of the Labrador retrievers.  Around 6-12 months of age, affected dogs develop dry, rough, gray to brown crusts and rarely painful cracks on the top of the nose.  The noses are then prone to superficial bacterial infections. Genetic testing of the SUV39H@ gene will reliably determine if a dog is a carrier.

 

Hyperuricosuria 

Inherited condition of the urinary system affecting several breeds of dog.  Genetic testing of SLC2a9 will reliably determine whether a dog is a genetic carrier.

 

Neonatal Encephalopathy

Inherited neurological disease known to affect dogs. By three weeks of age, surviving puppies present with neurological symptoms involving muscle weakness, tremors, inability to walk, wide based stance and frequent falling. Genetic testing of the ATF2 gene in Labradoodles wall determine whether a dog is a genetic carrier.

 

Progressive Retina atrophy

Late onset, inherited eye disease affecting dogs.  Genetic testing of the TTC8 gene in labradoodles will determine whether a dog Is a carrier.

 

Retinal Dysplasia/Oculoskeletal Dysplasia

Inherited collagen disorder. Genetic testing of the COL9A3 will reliably determine whether a dog is genetic carrier.

 

Von Willebrand Disease I (vwd)

Inherited bleeding disorder affecting labradoodles.  Genetic testing of the VWF gene in Labradoodles will determine whether a dog is a genetic carrier.

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